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. Author manuscript; available in PMC: 2008 Oct 27.
Published in final edited form as: Crit Care Med. 2008 Aug;36(8):2355–2362. doi: 10.1097/CCM.0b013e31818024f6

Figure 5.

Figure 5

Effect of ascorbate bolus (10 mg/kg, given at 6 hrs post-FIP) on plasma ascorbate concentration at 7 hrs post-FIP and on survival at 24 hrs, in wild type mice. Panel A: Control and septic mice were injected iv with saline or ascorbate at 6 hrs, and blood samples were collected at 7 hrs post-FIP. Analysis by two-way ANOVA revealed no significant effect of sepsis or ascorbate on plasma ascorbate concentration at 7 hrs (n = 5 and 6 for saline injected control and septic mice, and 5 and 7 for ascorbate injected control and septic mice, respectively). Panel B: Septic mice were monitored every 6 hrs for 24 hrs. Based on Kaplan-Meier survival analysis, survival of mice given ascorbate at 6 hrs post-FIP (n = 32) was significantly higher (p < 0.05) than that of mice given saline (n = 31).