Table 3. Genotype Distribution by TT Status Based on Univariate Analysis.
| Gene category | Gene (SNP) | Genotype | TT (n = 135) | Controls (n = 232) | p-value |
| Proinflammatory cytokine genes | TNFA (−308 G>A) | GG | 91 (67%) | 105 (45%) | <0.001 |
| GA | 41 (30%) | 105 (45%) | |||
| AA | 3 (3%) | 22 (10%) | |||
| LTA (252 G>A) | GG | 51 (38%) | 55 (24%) | <0.001 | |
| GA | 70 (52%) | 116 (50%) | |||
| AA | 14 (10%) | 61 (26%) | |||
| IL1A (−889 C>T) | CC | 5 (4%) | 11 (5%) | 0.002 | |
| CT | 55 (41%) | 127 (55%) | |||
| TT | 75 (56%) | 94 (40%) | |||
| IL1B (F105F) | CC | 116 (86%) | 160 (69%) | <0.001 | |
| CT | 18 (13%) | 72 (31%) | |||
| TT | 1 (1%) | 0 | |||
| IL6 (−174 C>G) | CC | 123 (91%) | 227 (98%) | 0.02 | |
| CG | 11 (8%) | 5 (2%) | |||
| GG | 1 (1%) | 0 | |||
| Adhesion molecule genes | VCAM1 (−1594 T>C) | TT | 89 (66%) | 118 (51%) | 0.001 |
| TC | 35 (26%) | 104 (45%) | |||
| CC | 11 (8%) | 10 (4%) | |||
| Th1/Th2/Th3 cytokines and related genes | IL4 (−589 C>T) | CC | 32 (24%) | 25 (11%) | 0.004 |
| CT | 64 (47%) | 125 (54%) | |||
| TT | 39 (29%) | 82 (35%) | |||
| IL4R (Q576R) | AA | 71 (53%) | 79 (43%) | <0.001 | |
| AG | 53 (39%) | 141 (51%) | |||
| GG | 11 (8%) | 12 (6%) | |||
| IL4R (I50V) | AA | 37 (28%) | 67 (29%) | 0.017 | |
| AG | 60 (44%) | 128 (55%) | |||
| GG | 38 (28%) | 37 (16%) | |||
| IL9 (T113M) | CC | 126 (93%) | 158 (68%) | <0.001 | |
| CT | 9 (7%) | 73 (32%) | |||
| TT | 0 | 1 (0.4%) | |||
| Chemokines and related genes | CCR3* (P39L) | CC | 133 (98%) | 202 (88%) | 0.001 |
| CT | 1 (0.1%) | 28 (12%) | |||
| TT | 1 (0.1%) | 0 | |||
| Miscellaneous | ADRB2 (Q27E) | CC | 99 (74%) | 134 (58%) | 0.011 |
| CG | 33 (24%) | 90 (39%) | |||
| GG | 3 (2%) | 8 (3%) | |||
| ADRB2* (T164I | CC | 312 (87.1%) | 177 (100) | 0.001 | |
| CT | 45 (12.6%) | 0 | |||
| TT | 1 (0.3%) | 0 | |||
| CTLA4 (−318 C>T) | CC | 98 (73%) | 134 (58%) | 0.016 | |
| CT | 34 (25%) | 92 (40%) | |||
| TT | 3 (2%) | 6 (2%) | |||
| NOS2A (D346D) | CC | 101 (75%) | 137 (59%) | 0.007 | |
| CT | 34 (25%) | 93 (40%) | |||
| TT | 0 | 2 (1%) | |||
| NOS3 (E298D) | GG | 94 (70%) | 192 (83%) | 0.014 | |
| GT | 39 (29%) | 38 (16%) | |||
| TT | 2 (1%) | 2 (1%) |
*
Total number of controls were 230 for ADRB2(T164I), CCR3(P39L), total number of TT cases were same as all (n = 135).