Table 6.
Clinical outcomes in relation to histologic diagnosis in 53 patients with C1q nephropathy
| Clinical Outcomes | Light Microscopy Findings
|
||||
|---|---|---|---|---|---|
| No Lesions (n = 6) | No Lesions (with NS) (n = 13) | FSGS (with NS) (n = 9) | Proliferative GN (n = 14) | Other (n = 11)a | |
| Follow-up (yr; range) | 0.5 to 15.0 | 0.3 to 21.0 | 1.0 to 9.0 | 0.5 to 12.0 | 0.5 to 14.0 |
| Follow-up (yr; mean ± SD) | 5.4 ± 6.0 | 7.1 ± 7.4 | 2.9 ± 2.5 | 4.9 ± 3.5 | 6.5 ± 4.7 |
| Normal/complete remission (n [%]) | 2 (33.3) | 10 (76.9) | 3 (33.3) | 2 (14.3) | 0 (0.0) |
| Partial remission (n [%]) | 1 (16.7) | 3 (23.1) | 2 (22.2) | 0 (0.0) | 2 (18.2) |
| Treatment resistant NS (n [%]) | 0 (0.0) | 0 (0.0) | 1 (11.1) | 0 (0.0) | 0 (0.0) |
| Stable renal disease (n [%]) | 3 (50.0) | 0 (0.0) | 0 (0.0) | 8 (57.1) | 4 (36.4) |
| Progression of renal disease (n [%]) | 0 (0.0) | 0 (0.0) | 0 (0.0) | 2 (14.3) | 2 (18.2) |
| ESRD (n [%]) | 0 (0.0) | 0 (0.0) | 3 (33.3) | 2 (14.3) | 3 (27.2) |
a
Tubulointerstitial nephritis (n = 2), Hantavirus nephropathy (n = 1), benign hypertensive nephrosclerosis (n = 2), thin basement membrane nephropathy (n = 2), autosomal recessive polycystic kidney disease (n = 1), and medullary cystic disease (n = 1).