Table 1.
Baseline characteristics of study patients, stratified by statin use at time of transplantationa
| Characteristic | No. of Patients (Statin/No Statin) | Statins | No Statins | P |
|---|---|---|---|---|
| Recipient age (mean [SD]) | 2041 (302/1739) | 54 (11.8) | 47 (15.8) | <0.001 |
| Donor age (mean [SD]) | 1962 (285/1677) | 46.8 (15.3) | 42.7 (16.1) | <0.001 |
| Recipient female gender (n [%]) | 1971 (286/1685) | 127 (44.4) | 664 (39.4) | 0.110 |
| Donor female gender (n [%]) | 1971 (286/1685) | 127 (44.4) | 673 (39.9) | 0.160 |
| Cadaveric organ donor (n [%]) | 2041 (302/1739) | 276 (91.4) | 1576 (90.6) | 0.670 |
| Time on dialysis (yr; median [IQR]) | 2041 (302/1739) | 2.2 (1.2 to 3.3) | 1.7 (0.8 to 3.0) | 0.002 |
| Body weight, kg (mean [SD]) | 1337 (241/1096) | 74 (14.1) | 70 (16.8) | <0.001 |
| Diabetes (%) | 2041 (302/1739) | 98 (32.5) | 285 (16.4) | <0.001 |
| HbA1c level (%; median [IQR]) | 1185 (229/958) | 6.2 (5.7 to 6.9) | 6.1 (5.6 to 6.6) | 0.033 |
| Panel reactive antibodies (%; median [SD]) | 1949 (298/1651) | 4.0 (10.9) | 5.2 (14.1) | 0.150 |
| Sum of HLA mismatches (mean [SD]) | 1819 (291/1528) | 2.7 (1.4) | 2.4 (1.5) | 0.006 |
| Cold ischemic time (h; mean [SD]) | 1768 (258/1510) | 14.5 (7.5) | 18.3 (8.4) | <0.001 |
| Arterial hypertension (n [%]) | 2041 (302/1739) | 292 (96.7) | 1364 (78.4) | <0.001 |
| No. of BP drugs (median [IQR]) | 2041 (302/1739) | 3 (2 to 4) | 2 (0 to 3) | <0.001 |
| SBP (mmHg; mean [SD]) | 1253 (227/1026) | 138.7 (15.9) | 140.2 (39.0) | 0.570 |
| DBP (mmHg; mean [SD]) | 1253 (227/1026) | 82.9 (48.7) | 82.5 (24.0) | 0.840 |
| Cholesterol level, mg/dl (mean [SD]) | 1636 (293/1343) | 205.5 (53.0) | 207.9 (77.9) | 0.610 |
| Coronary heart disease (n [%]) | 1242 (250/992) | 79 (31.6) | 238 (24.0) | 0.014 |
| Other heart disease (n [%]) | 1236 (250/992) | 120 (48.0) | 391 (39.7) | 0.017 |
| Vascular disease (n [%]) | 1159 (244/915) | 79 (32.4) | 254 (27.8) | 0.160 |
a
DBP, diastolic BP; SBP, systolic BP.