Figure 2. Quantifying fidelity in signal recognition using two metrics.

(A) Dose responses of D₁ and D₂ to A₁ and A₂ respectively. f_a is evaluated at the signal concentration (K_1/2) that leads to half-maximum induction of D₁. f_s is evaluated at a saturating signal concentration.

(B) Modulation of fidelity (f_a or f_s) by α (for β = γ =10), which characterizes the differential protein stabilization by A₁ and A₂. A similar trend is observed for other values of β and γ (Figure S1).