Fig. 1. (A) Mean blood pressure (MBP) profile in Dahl rats at 0, 1, 2, 3, and 4 weeks.
*P < 0.05 vs. baseline. †P < 0.05 vs. DS/L rats. (B) Urinary protein excretion in Dahl rats at 4 weeks. MBP and urinary protein excretions in DS/H rats were significantly higher than those in DS/L, DR/H, and DR/L rats. Candesartan treatment did not alter MBP but significantly decreased urinary protein excretion in DS/H rats. *P < 0.05 vs. DS/L rats. DR/L rats: Dahl salt-resistant rats fed a 0.3% NaCl diet; DR/H rats: Dahl salt-resistant rats fed an 8% NaCl diet; DS/L rats: Dahl salt-sensitive rats fed 0.3% NaCl diet; DS/H rats: Dahl salt-sensitive rats fed an 8% NaCl diet; C: candesartan.