Table 1.
Effects of 4 weeks of a high-salt diet and candesartan (C) on body weight (BW), kidney weight (KW), urinary excretions of sodium (UNaV) and potassium (UKV), and kidney collagen content in Dahl salt-resistant (DR) rats and Dahl salt-sensitive (DS)
| DR rats |
DS rats |
|||||
|---|---|---|---|---|---|---|
| Low salt (N = 7) | High salt (N = 7) | High salt + C (N = 7) | Low salt (N = 7) | High salt (N = 9) | High salt + C (N = 9) | |
| BW g | 321 ± 2 | 319 ± 4 | 313 ± 4 | 342 ± 3 | 334 ± 2 | 346 ± 2 |
| KW g | 1.16 ± 0.04 | 1.21 ± 0.01 | 1.11 ± 0.03 | 1.31 ± 0.03 | 1.91 ± 0.06a | 1.69 ± 0.03a,b |
| KW/BW % | 0.36 ± 0.01 | 0.38 ± 0.01 | 0.34 ± 0.01 | 0.38 ± 0.01 | 0.56 ± 0.02a | 0.49 ± 0.01a,b |
| UNaV mEq/day | 1.1 ± 0.3 | 16.7 ± 1.4a | 20.6 ± 1.8a | 0.8 ± 0.1 | 19.2 ± 1.8a | 23.7 ± 1.4a |
| UKV mEq/day | 1.1 ± 0.1 | 3.8 ± 0.1a | 4.1 ± 0.2a | 1.1 ± 0.1 | 4.0 ± 0.2a | 4.6 ± 0.1a |
| Kidney collagen content μg/mg dry weight | 12 ± 2 | 13 ± 1 | 10 ± 1 | 12 ± 3 | 24 ± 1a | 16 ± 1a,b |
Values are mean ± SE.
a
P < 0.05 vs. the same strain on a low salt diet.
b
P < 0.05, DS/a high salt diet vs. DS/a high salt diet + candesartan.