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A model illustrating the molecular basis for regulation of the hXOR promoter. In this model SAFB1 binds to the consensus E-box (ACAGGTG) and restricts hXOR promoter activity and interacts with other co-repressors, such as Ku86, SAFA, and BRG1. Ku86 is associated with Ku70 and DNA-PKcs. Based on EMSA, other unknown transcription factors that may be involved in the regulation of hXOR are labeled with capital letters (A–C).
