TABLE 1.
Demographic and main clinical characteristics of the study populationa
| Characteristic | Value for:
|
Pb | ||
|---|---|---|---|---|
| All patients | Virological responders | Virological nonresponders | ||
| No. (%) of patients | 37 | 21 (56.8) | 16 (43.2) | |
| HIV-1 RNA load (log10 copies/ml) | 4.6 (3.8-4.9) | 4.4 (3.8-4.9) | 4.8 (3.9-5.1) | 0.490 |
| CD4+ T-cell count (cells/mm3) | 210 (95-303) | 238 (170-295) | 174 (51-333) | 0.265 |
| OBS | 1.5 (0.7-2.0) | 1.5 (0.7-2.2) | 1.5 (0.6-2.0) | 0.565 |
| No. of RAM in the PRO gene | 8 (6-11) | 9 (7-11) | 7 (4-10) | 0.918 |
| No. of DRV RAM | 1 (0-2) | 1 (0-2) | 1 (0-2) | 0.918 |
| Fold change in the DRV IC50 | 1.4 (0.6-3.5) | 1.2 (0.6-2.4) | 2.0 (0.6-9.3) | 0.651 |
| DRV Ctrough (ng/ml) | 3,518 (2,612-5,085) | 3,389 (2,961-4,656) | 3,361 (1,593-4,813) | 0.377 |
| DRV gIQ | 2,780 (1,937-3,396) | 3,144 (2,250-3,514) | 2,314 (1,459-3,382) | 0.353 |
| DRV vIQ | 4.1 (0.9-9.7) | 6.6 (1.9-10.5) | 1.4 (0.8-9.6) | 0.159 |
| No. (%) of patients with a DRV gIQ of >2,400 | 22 (59.5) | 15 (71.4) | 7 (43.8) | 0.105 |
| No. (%) of patients with a DRV vIQ of >1.5 | 24 (64.8) | 17 (70.8) | 7 (29.2) | 0.028 |
a
Data are expressed as the median (interquartile range), except where otherwise noted. PRO, protease; DRV, darunavir.
b
For difference between virological responders and nonresponders, determined by logistic regression analysis adjusted for the OBS.