TABLE 2.
In vitro fungistatic activities of oligopeptide antifungals and fluconazole against S. cerevisiae reference and recombinant strains
| Oligopeptide | MIC (μg/ml) ofa:
|
||||
|---|---|---|---|---|---|
| ATCC 9763 | AD | ADCDR1 | ADCDR2 | ADMDR1 | |
| 5FO-Leu-Leu (1) | 512 | 512 | 128 | 256 | 512 |
| OLys-Leu-Gly (2) | 8 | 4 | 1 | 1 | 4 |
| OLys-Leu-Leu-Gly (3) | 64 | 64 | 16 | 32 | 64 |
| OLys-Leu-Leu-Leu-Gly (4) | 256 | 256 | 128 | 128 | 256 |
| Leu-FPhe (5) | 256 | 256 | 8 | 4 | 256 |
| Met-Met-FPhe (6) | 256 | 512 | 32 | 32 | 256 |
| Nva-FMDP (7) | 4 | 4 | 0.5 | 1 | 4 |
| Lys-Nva-FMDP (8) | 32 | 32 | 4 | 8 | 32 |
| Nikkomycin (9) | 128 | 128 | 16 | 16 | 128 |
| Histatin 5 | 128 | 128 | 128 | 128 | 128 |
| Fluconazole | 2 | 1 | 32 | 16 | 32 |
a
MICs were determined as described in Materials and Methods by the microtiter serial twofold dilution method using the YNBG-proline medium containing 2% glucose. Inoculum size was 105 CFU/ml. Plates were incubated for 24 h at 30°C.