TABLE 3.
In vitro fungistatic activities of amino acid antifungals against S. cerevisiae reference and recombinant strains
| Amino acid | MIC(s) (μg/ml) ofa:
|
||||
|---|---|---|---|---|---|
| ATCC 9763 | AD | ADCDR1 | ADCDR2 | ADMDR1 | |
| Asp-γ-hydroxamate (10) | 256 | 256 | 64 | 64 | 128 |
| OLys (11) | 8 | 8 | 2 | 4 | 16 |
| FPhe (12) | 32 | 32 | 16 | 16 | 32 |
| cis-pentacin (13) | 64, 4b | 128, 8b | 256, 16b | 256, 16b | 256, 16b |
| DON (14) | 0.5 | 0.5 | 0.125 | 0.25 | 0.5 |
| Azaserine (15) | 2 | 2 | 1 | 1 | 2 |
a
MIC(s) determined under conditions described in Table 2.
b
MICs determined by using the YNBG medium containing 1 mg/ml of l-glutamate instead of l-proline as the main nitrogen source.