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(A) Mean plasma RPT concentrations versus time of RPT after a single 900-mg dose (▵) versus after seven doses of 900 mg thrice weekly (○). (B) Mean plasma 25-desacetyl-RPT concentrations versus time after a single 900-mg dose of RPT (▵) versus after seven doses of 900 mg given thrice weekly (○). Values shown represent arithmetic means with standard error bars.
