TABLE 1.
Effect of treatment with oseltamivir, ribavirin, and their combinations on the survival of mice inoculated with A/Vietnam/1203/04 (H5N1) influenza virus
| Oseltamivir (mg/kg/day) | Results obtained with the following ribavirin dose (mg/kg/day)a:
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0
|
37.5
|
75
|
|||||||
| No. of survivors/total no. of mice (%) | Day of death (mean ± SD) | Hazard ratiob | No. of survivors/total of mice (%) | Day of death (mean ± SD) | Hazard ratio | No. of survivors/total of mice (%) | Day of death (mean ± SD) | Hazard ratio | |
| 0 | 0/10 (0) | 10.9 ± 0.7 | 1 | 5/10 (50)* | 16.7 ± 1.4* | 0.21* | 7/10 (70)** | 14.9 ± 0.9* | 0.11* |
| 1 | 3/10 (30) | 11.8 ± 0.7 | 0.44 | 9/10 (90)**,°°,† | 15 | 0.03*,° | 9/10 (90)**, °° | 10 | 0.03*,° |
| 10 | 8/10 (80)** | 12.8 ± 0.3 | 0.07* | 7/10 (70)** | 14.2 ± 0.6*,† | 0.11* | 9/10 (90)** | 19 | 0.03* |
Boldface type indicates a higher percentage of survivors, a longer time to death, or a lower risk of death compared with the values obtained when either compound was used alone. *, P < 0.01, compared with the results for the placebo-treated control group; **, P < 0.001 compared with the results for the placebo-treated control group; °, P < 0.05, compared with the results for the group treated with oseltamivir alone; °°, P < 0.01, compared with the results for the group treated with oseltamivir alone; †, P < 0.05 compared with the results for the group treated with ribavirin alone.
An estimate of the relative risk of death.