FIG. 1.

Morbidity and mortality differ following infection of outbred mice with VEEV or EEEV. Adult, outbred CD-1 mice were infected with cDNA clone-derived ZPC738 VEEV or FL93-939 EEEV and monitored for morbidity and mortality as follows. (A and B) Percent survival following subcutaneous (A) or intracerebral (B) inoculation of CD-1 mice with 10³ PFU of VEEV (white circles, dashed line) or EEEV (black circles, solid line). (C and D) Clinical score over the disease course of mice infected subcutaneously with 10³ PFU of VEEV (C) or EEEV (D). Clinical scores to assess signs of disease in the mice were as follows: 0, healthy (white); 1, ruffled fur and behavioral changes (hatched); 2, paresis or ataxia (crosshatched); 3, moribund (gray); 5, dead (black). (E and F) Percent weight change over the disease course of mice that were infected subcutaneously (E) or intracerebrally (F) with 10³ PFU of VEEV (white circles) or EEEV (black circles). Data are representative of at least two independent experiments.