FIG. 2.
Replication and dissemination profiles of VEEV and EEEV differ in subcutaneously inoculated mice. CD-1 mice, infected with 103 PFU of ZPC738 VEEV (white circles) or FL93-939 EEEV (black circles) subcutaneously in each rear footpad, were sacrificed at various times p.i. Titers of virus from DLN (A), serum (B), spleen (C), ankle joint (D), bone aspirate (E), and brain (F) were determined. Values represent the geometric mean virus titers (log10 PFU/ml or g) for three mice, determined on BHK cells, and are shown ± standard deviations. Dotted line denotes inoculum dose (A) or limit of detection (B to F).