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. 2008 Aug 20;82(21):10418–10428. doi: 10.1128/JVI.01190-08

FIG. 5.

FIG. 5.

Distribution of memory markers. Cells from CSF and blood were assessed for distribution of CD45RO and CCR7 T-cell differentiation markers on CD4+, CD8+, and HIV-specific tetramer-positive cells by flow cytometry. (A) Flow cytometric plots of CD45RO and CCR7 on CD8+, CD4+, and HIV-specific tetramer-positive (B57-KF11) cells from CSF and blood of one representative participant (10027). Numbers in plots represent frequencies of cells in the quadrant as percentages of CD8+, CD4+, and tetramer-positive T cells. TCM, CD45RO+ CCR7+; TEMRO, CD45RO+ CCR7−; TEMRA, CD45RO− CCR7−; naïve T cells, CD45RO− CCR7+. (B) Relationship between the frequencies of CD45RO+ cells among CD8+, CD4+, and tetramer-positive cells from CSF and blood. (C) Relationship between the frequencies of TEMRA (CD45RO− CCR7− T cells) among tetramer-positive cells from CSF and blood. CCR7 stains were done for only three participants from whom we had a sufficient number of cells (>1.0 × 105) from CSF. The diagonal dashed line represents the line of unity. The P values are derived from a two-tailed Wilcoxon matched-pairs t test.