FIG. 10.

Model showing how gE/gI and US9 might facilitate the loading of HSV capsids onto microtubules within neuronal-cell bodies. TGN membrane vesicles containing gE/gI and present in neuronal-cell bodies are adjacent to microtubules and serve as platforms for the assembly or loading of HSV tegument-coated capsids onto microtubule motors prior to transport into and down axons. HSV US9 may be a membrane protein and act similarly, or it may be a tegument protein bound to the surfaces of capsids.