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Location of second-site mutations identified in Con1 NS3. (A) Space-filling view of the NS3-4A dimer derived from HCV genotype 1 (Protein Data Bank accession number, 1CU1) (44). The cofactor peptide of NS4A (residues 1678 to 1690 in the polyprotein) is shown in purple and the location of the second-site mutations is shown in red on chain A and yellow on chain B. (B) Flipped view displaying the back side of the NS3-4A dimer. Images were generated using Pymol (pymol.sourceforge.net).
