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. 2008 Aug 20;82(21):10366–10374. doi: 10.1128/JVI.00470-08

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Copyright © 2008, American Society for Microbiology

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FIG. 3. — Classical IVS of EVG-resistant HIV-1 strains. MT4-LTR-EGFP cells were infected with HIV-1 IIIB (black star) and grown in the presence of EVG. Cells were passaged every 3 to 4 days (small squares). When full virus breakthrough was observed (black dots), viruses were harvested, and the concentration of EVG was doubled. Genotypes of harvested viruses are indicated next to the black dots; phenotypes (EVG EC₅₀) of viruses IIIB/GS-9137(#9), IIIB/GS-9137(#13), IIIB/GS-9137(#22), and IIIB/GS-9137(#41) were determined using a cellular antiviral assay.