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. 2008 Aug 20;82(21):10820–10831. doi: 10.1128/JVI.00365-08

FIG. 6.

FIG. 6.

NK cells mediate functional improvement and avidity maturation of anti-HSV CD8+ T cells. HSV memory C57BL/6 mice were grouped and treated as described in the legend to Fig. 5. The splenocytes were briefly stimulated (2 h) with the HSV immunodominant SSIEFARL (gB 498 to 505) peptide. This was followed by staining with anti-IL-15Rα and anti-CD8β Abs. HSV gB peptide-specific CD8+ T cells were analyzed for the expression of IL-15Rα and CD8β by gating CD69-positive CD8+ T cells. The dot plot represents the IL-15Rα- and CD8β-expressing HSV-specific CD8+ T cells in the four groups mentioned above. The experiment was repeated three times with similar patterns of results. The number within the plot is the mean ± SD from one such experiment. One-way analysis of variance indicates the difference between the groups to be significant (P < 0.0001).