FIG. 4.

Representation displaying the structure homology of the miR302-367 locus. The upper part of the figure depicts a schematic representation of the human miR302-367 locus. The transcriptional start (+1) is shown. Black arrows represent the miRNA precursor. Gray boxes represent the miR302-369 exons. Lined boxes indicate the introns. The polyadenylation signal is represented as gray vertical lines. The conserved promoter sequence is identified upstream of the transcriptional start as a dotted arrow. White arrows represent LARP7 exons. Alternative splicing of the primary RNA is also shown. The lower part of the figure shows an overall profile of sequence similarity (represented in red) obtained from the multiple alignment of H. sapiens (hs), M. musculus (mm), C. familiaris (cf), and B. taurus (bt) homologues. Multiple sequence alignment was performed using the Lagan program of Vista tools.