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The TLR3 mRNA level is downregulated in tissues of p53−/− mice. (A to C) Total RNA isolated from liver (A), intestine (B), and spleen (C) of p53+/+, p53+/−, and p53−/− mice was analyzed for the expression of TLR3 by real-time quantitative RT-PCR. TLR3 mRNA levels were normalized to HPRT (internal control). The results represent means ± standard deviations (n = 3). * and **, P < 0.01 and P < 0.001, respectively, against p53 wild-type mice (+/+), as assessed by ANOVA with Dunnett's test.
