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Proposed model for HCV-induced AR activation. Inflammatory cytokine IL-6 activates STAT3 signaling. HCV also enhances the phosphorylation of Tyr-705 and Ser-727 of STAT3 through the core protein and enhances AR expression. AG490, a JAK-1 protein inhibitor, inhibits the JAK/STAT signaling pathway, suggesting an association of STAT3 as a downstream modulator.
