TABLE 4.
Mutations and rearrangements detected in individual CPV sequences after experimental passage in catsa
| Area of isolation | Gene region | nt position | Amino acid change | Observed in nature | Functional implication |
|---|---|---|---|---|---|
| Feces | NS1 | 941 | — | Yes | — |
| Feces | NS1 | 1319 | — | Yes | — |
| Feces | NS1/NS2 | 2024 | T94A (NS2) | Yes | Intracellular traffickingb |
| Feces | NS1/NS2 | 2198 | M152V (NS2) | Yes | Interaction with members of the 14-3-3 protein familyb |
| Feces | VP2 | 2798 | Start codon | No | VP2 start codon |
| Bone marrow | NS1/NS2 | 1855 | D528V | Yes | VP2 phosphorylationb |
a
Samples from cat 1 were used. Single mutations in samples collected after experimental infection with CPV-13.us.81 are shown. Mutations also observed in GenBank sequences are indicated by boldface type. —, not applicable.
b
Functions represent comparable functions seen in the related minute virus of mice. The respective protein function has not been analyzed for FPV or CPV.