FIG. 1.

TV genome organization and mutations identified in the genome of cell culture-adapted TV. (A) Organization of TV genome. The open box represents ORF1, the gray box represents ORF2, and the black box represents ORF3. The initial nucleotide for each ORF is in lightface font, and the end nucleotide for each ORF is in italics. (B) Mutation identified in the genome of cell culture-adapted TV. The black bar represents the TV genome. The numbers above the bar correspond to mutation sites. Mutated nucleotides are highlighted in bold, whereas mutations resulting in amino acid substitutions are underlined.