FIG. 2.

RRV titers in joint and skeletal muscle tissue. Twenty-four-day-old C57BL/6J WT (filled circles) or CD11b^−/− (open circles) mice were infected with 10³ PFU of RRV by injection in the left rear footpad. At 1 (n = 6), 3 (n = 5), 5 (n = 5 or 6), and 7 (n = 5) dpi, mice were sacrificed and extensively perfused with 1× PBS. Ankles and quadriceps were dissected, weighed, and homogenized, and the amount of infectious virus present was quantified by plaque assays. (A) Left ankles. (B) Right ankles. (C) Left quadriceps. (D) Right quadriceps. Horizontal bars indicate the means. No statistically significant differences between WT mice and CD11b^−/− mice were detected by ANOVA at any time point.