TABLE 5.
Comparison of complete genomic sequences of Oka-P and Oka-V strains of VZVa
| Feature relative to WT (Dumas) | Position (WT) | Feature in:
|
Position in:
|
||||
|---|---|---|---|---|---|---|---|
| Oka-P | Oka-V | Oka-VGSK | Oka-VMerck | Oka-VGSK | Oka-VMerck | ||
| T→C | 560 | - | X | X | X | 559 | 559 |
| T→T/C (ORF 1), Q, silent | 703 | - | X | C | C | 702 | 702 |
| T→T/C (ORF 1), P, silent | 763 | - | X | C | C | 762 | 762 |
| C→G (ORF 2), G, silent | 1838 | - | X | - | - | 1837 | 1837 |
| T→T/C | 2515 | - | X | C | - | 2514 | 2514 |
| A→G (ORF 6), S→P | 5745 | - | X | X | A/G | 5744 | 5744 |
| T→C/T (ORF 9A), W→R | 10900 | - | X | X | - | 10899 | 10899 |
| C→C/T (ORF 10), A→V | 12779 | - | X | X | - | 12778 | 12778 |
| Insertion (ORF 11, R1), CGCGATCGACGACGAGGGAGAGGCGGAGGAGGA | 14242 | X | X | X | 14164-14196 | 14164-14196 | |
| T→T/C (ORF 14), stop | 19431 | - | X | - | - | 19385 | 19385 |
| A→G (ORF 18), N, silent | 26125 | - | X | X | A/G | 26076 | 26076 |
| C→T/C (ORF 21), T→I | 31732 | - | X | - | - | 31683 | 31683 |
| T→T/G (ORF 22), P, silent | 39227 | - | X | X | - | 39178 | 39178 |
| C→T (R3 repeat), A→V | 41476 | X | X | X | 41427 | 41427 | |
| Deletion, GCGCAGCCC | 41475-83 | - | X | - | - | 41426-41434 | 41426-41434 |
| G→C (R3 repeat), A→V | 41476 | X | X | X | 41427 | 41427 | |
| Deletion/insertion | 42403 | Del AAA | Del AA | Ins A | Del A | 42355 | 42353 |
| A→G (ORF 31), I→V | 58595 | - | A/G | A/G | X | 58531 | 58529 |
| A→A/G (ORF 31), P, silent | 59287 | - | X | X | X | 59223 | 59221 |
| A→G (ORF 35), A, silent | 64067 | - | X | X | A/G | 64003 | 64000 |
| T→C (ORF 39), M→T | 71252 | - | X | X | C/T | 71188 | 71185 |
| A→A/G (ORF 45), P, silent | 82225 | - | X | - | - | 82160 | 82157 |
| G→A/G (ORF 47), E, silent | 84091 | - | X | - | - | 84026 | 84023 |
| A→A/G (ORF 50), C, silent | 87280 | - | X | - | - | 87205 | 87202 |
| T→C/T (ORF 50), S→G | 87306 | - | X | - | - | 87231 | 87228 |
| A→G (ORF 51), T, silent | 89734 | - | X | X | - | 89659 | 89656 |
| A→A/G (ORF 52), I→V | 90535 | - | X | X | - | 90460 | 90457 |
| T→C (ORF 54), L, silent | 94167 | - | X | X | T/C | 94092 | 94089 |
| G→A/G (ORF 55), A→T | 97748 | - | X | X | X | 97673 | 97670 |
| T→C/T (ORF 55), C→R | 97796 | - | X | X | - | 97721 | 97718 |
| Insertion, C | 105020 | X | X | X | 104946 | 104943 | |
| A→A/G | 105169 | - | X | X | X | 105097 | 105094 |
| A→A/G (ORF 62), L→S | 105310 | - | X | X | X | 105238 | 105235 |
| T→C (ORF 62), I→V | 105356 | - | X | X | T/C | 105284 | 105281 |
| A→G (ORF 62), V→A | 105544 | - | X | X | X | 105472 | 105469 |
| T→C (ORF 62), A, silent | 105705 | - | X | X | X | 105633 | 105630 |
| T→C (ORF 62), R→G | 106262 | - | X | X | X | 106190 | 106187 |
| T→C (ORF 62), A, silent | 107136 | - | X | X | T/C | 107064 | 107061 |
| T→C (ORF 62), S→G | 107252 | - | X | X | X | 107180 | 107177 |
| A→A/G (ORF 62), V→A | 107599 | - | X | X | - | 107527 | 107524 |
| T→C (ORF 62), P, silent | 108111 | - | X | X | X | 108039 | 108036 |
| A→A/G (ORF 62), M→T | 108838 | - | X | X | X | 108766 | 108763 |
| A→A/G | 109137 | - | X | X | X | 109065 | 109062 |
| A→A/G | 109200 | - | X | X | 109128 | 109125 | |
| Insertion, GGGAGGGGGCGCGGTACCCCGCCGATG | 109907 | X | - | - | - | 109838 | 109835 |
| Deletion, AT | 110212 | - | X | X | - | 110142 | 110140-110141 |
| Insertion, ATATAG | 110214 | X | - | - | - | 110142 | 110141 |
| A→G (ORF 64), Q→R | 111650 | - | X | A/G | A/G | 111576 | 111575 |
| T→C (ORF 69), Q→R | 118247 | - | X | T/C | T/C | 118183 | 118174 |
| A→C (Ori) | 119677 | X | - | X | X | 119611 | 119602 |
| Deletion, ATATATAT | 119677-119684 | - | X | - | - | 119611-119618 | 119602-119609 |
| A→C (Ori) | 119679 | X | - | X | X | 119613 | 119604 |
| A→C (Ori) | 119681 | X | - | X | X | 119615 | 119606 |
| A→C (Ori) | 119683 | X | - | X | A/C | 119617 | 119608 |
| Insertion, TACCGCGCCCCCTCCCCATCGGCGGGG | 120135 | X | - | - | - | 120068 | 120060 |
| T→T/C | 120697 | - | X | X | 120633 | 120624 | |
| T→T/C | 120760 | - | X | X | X | 120696 | 120687 |
| T→C/T (ORF 71), M→T | 121059 | - | X | X | X | 120995 | 120986 |
| A→G (ORF 71), P, silent | 121786 | - | X | X | X | 121722 | 121713 |
| T→C/T (ORF 71), V→A | 122298 | - | X | X | 122234 | 122225 | |
| A→G (ORF 71), S→G | 122645 | - | X | X | X | 122581 | 122572 |
| A→G (ORF 71), A, silent | 122761 | - | X | X | A/G | 122697 | 122688 |
| A→G (ORF 71), R→G | 123635 | - | X | X | X | 123571 | 123563 |
| A→G (ORF 71), A, silent | 124192 | - | X | X | X | 124128 | 124119 |
| T→C (ORF 71), V→A | 124353 | - | X | X | X | 124289 | 124280 |
| A→G (ORF 71), I→V | 124541 | - | X | X | A/G | 124477 | 124468 |
| T→C (ORF 71), L→S | 124587 | - | T/C | T/C | T/C | 124523 | 124514 |
| T→T/C | 124728 | - | X | X | X | 124664 | 124655 |
a
Ori, origin of replication; WT, wild type. X, difference relative to Dumas strain; -, identical nucleotide relative to Dumas strain; Del, deletion; Ins, insertion. Where applicable, the resulting codon switch is specified. Boldface highlights homologies between genomic sequences of Oka-V and genomic sequences of Oka-VGSK and/or Oka-VMerck.