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Effect of miR122 target sites on viral replication in liver-derived and control cells. Huh7 and A549 cells were infected with Ad5/3K (AdK) or Ad5/3K-122 (K122) at a MOI of 0.05, and the titers of cell-associated infectious virus at three (A549) or five (Huh7) days postinfection were determined by a standard 50% tissue culture infective dose limiting dilution method. Values are expressed as PFU per milliliter.
