FIG. 1.

Hepatic immunopathology, worm burdens, and egg counts in CBA mice coinfected with H. polygyrus and S. mansoni. (A) Hepatic granulomatous inflammation, measured as described in Materials and Methods, was significantly decreased in CBA mice coinfected with H. polygyrus and S. mansoni compared with control CBA mice infected with S. mansoni alone. (B and C) There were no significant differences in the numbers of (B) S. mansoni worms or (C) S. mansoni eggs between CBA mice infected with schistosomes alone and CBA mice coinfected with H. polygyrus. Thirteen to 23 1-mm² fields were counted for each liver section, and 10 livers were counted for each mouse group. The immunopathology, worm, and egg data are representative of the results of two or three independent experiments. Sm, S. mansoni; Hp, H. polygyrus; ns, not significant.