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. 2008 Aug 25;76(11):4913–4923. doi: 10.1128/IAI.00569-08

FIG. 3.

FIG. 3.

Low dietary protein reduces day 3 T-cell counts and inflammation in B6 mice. The ratio of parameter levels between low- and high-protein diets is shown for B6 and A/J mice at low (A and C) and high (B and D) dietary antioxidant levels. Black bars indicate significant differences (n = 10 mice/group; P < 0.05 by Tukey HSD test). Protein reduction consistently decreased inflammation (Tim3/GATA3, Arg1, NOS2, and Ptgs2) in B6 mice (A and B). This decrease was more pronounced at low antioxidant levels with lower cell numbers (PBGD intron), pan-T cells (CD3δ), Th1 cells (Tim3), and naïve and memory T cells (CD45RB and CD45RO), and lower inflammatory cytokines (IL-6, TNF-α, IFN-γ, CxCl2, and IL-10) (A). However, protein reduction at both antioxidant levels in A/J mice increased day 3 inflammation (Tim3/GATA3 and Ptgs2) and T-cell populations (CD3δ and perforin 1) but decreased anti-inflammatory Th2 cell (GATA3) and naïve T-cell (CD45RB) populations (C and D).