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. 2008 Aug 25;76(11):4913–4923. doi: 10.1128/IAI.00569-08

FIG. 4.

FIG. 4.

Low levels of dietary antioxidants marginally influence day 3 lung transcripts. The ratio of parameter levels between low- and high-antioxidant diets is shown for B6 and A/J mice at low (A and C) and high dietary protein levels (B and D). Black bars indicate significant differences (n = 10 mice/group; P < 0.05 by Tukey HSD test). Overall, antioxidant reduction did not exert consistent effects across mouse strains and dietary protein levels. Most significantly, antioxidant reduction at low dietary protein concentrations reduced pan-T (CD3δ) and B (CD19) lymphocytes in B6 as well as A/J mice (A and C) and increased levels of macrophages (F4/80), Th1 and Th2 cells (Tim3 and GATA3), naïve T cells (CD45RB), and IL-10 in A/J mice (C). At high dietary protein concentrations, an antioxidant reduction increased levels of T-cell and inflammation transcripts (CD3δ, CD45RB, CD45RO, and Ptgs2) and decreased levels of macrophages (F4/80) in B6 mice (B).