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. 2008 Aug 25;76(11):4913–4923. doi: 10.1128/IAI.00569-08

FIG. 5.

FIG. 5.

Host genetic background determines profound and diet-dependent differences in early response to C. pneumoniae. The ratio of parameter levels between B6 and A/J mice is shown for all diets (A, LL; B, LH; C, HL; D, HH). Black bars indicate significant differences (n = 10 mice/group; P < 0.05 by Tukey HSD test). The dominant protein modulation of the response to C. pneumoniae is evident in the conserved patterns with low dietary protein (A and B) and the different conserved patterns with high dietary protein (C and D) irrespective of dietary antioxidant levels. Compared to A/J mice, B6 mice showed increased levels of neutrophils (lactoferrin) and arginase 2 (Arg2) but reduced levels of naïve and memory T cells (CD45RB and CD45RO) and Th2 anti-inflammatory markers (GATA3 and IL-10) virtually across all diets. Low dietary protein, particularly when combined with low levels of antioxidants (A), induced in B6 mice profoundly lowers cellular infiltration (PBGD intron, CD3δ, Tim3, GATA3, CD45RB, CD45RO, and perforin 1) and inflammation (Arg1, NOS2, Cybb, Ptgs2, IL-6, TNF-α, IFN-γ, Cxcl2, and IL-10).