TABLE 2.
Infection strain | Mean inflammation value (% of lung section inflamed) for the group at:a
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---|---|---|---|---|
4 wk postchallenge
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20 wk postchallenge
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Naïve mice | BCG-vaccinated mice | Naïve mice | BCG-vaccinated mice | |
Erdman | 48.8 ± 3.0 | 13.1 ± 2.1** | 38.7 ± 1.5 | 25.5 ± 1.1** |
C913 | 36.4 ± 4.2 | 24.8 ± 2.4* | 34.0 ± 0.8 | 18.0 ± 1.7** |
CDC1551 | 72.3 ± 2.5 | 35.9 ± 1.8** | 37.8 ± 1.7 | 23.6 ± 2.5** |
ChS | 34.4 ± 2.5 | 11.7 + 4.3** | 53.9 ± 7.7 | 24.4 ± 1.3** |
HN878 | 49.3 ± 4.0 | 16.5 ± 1.4** | 43.6 ± 5.2 | 23.2 ± 2.7* |
N4 | 39.6 ± 3.4 | 15.4 ± 3.8* | 47.3 ± 9.0 | 15.2 ± 2.5* |
NHN5 | 35.3 ± 3.7 | 24.7 ± 2.8* | 42.7 ± 2.9 | 16.8 ± 1.4** |
NY669 | 47.5 ± 7.0 | 16.0 ± 0.6** | 56.1 ± 0.2b | 29.9 ± 3.5* |
NY920 | 38.9 ± 5.8 | 19.4 ± 1.2** | 36.3 ± 6.2 | 20.1 ± 4.4* |
Mean percentage of the area of inflammation ± standard error of the mean. Significantly reduced lung inflammation in the BCG-vaccinated mice relative to naïve controls is indicated as follows: *, P < 0.05; **, P < 0.01.
Since naïve mice infected with NY669 died prior to the 20-week time point, these mice were sacrificed at 16 weeks postchallenge.