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Structural relationship among protease residues 30, 88, and 90. (A) Superimposition of the three-dimensional structures of mutant viruses reported by Mahalingam et al. containing D30N alone (2F80, blue ribbon), N88D alone (1FG 8, green ribbon), and I90M alone (2F8, red ribbon).8 (B) van der Waals surfaces of wild-type residues D30, N88, and L90 deduced from wild-type protease complexed with the PI TMC114 (1T7J).9
