Fig. 3. Correlations among the 18 known NRTI resistance mutations as well as the nine newly identified mutations.

Blue lines indicate positions with positive correlation coefficients > 0.27. Red lines indicate positions with negative correlation coefficient. The width of each line is linearly proportional to the value of the correlation coefficient. All positive correlations were statistically significant at P = 0.05 using a Bonferroni correction for 351 pairwise comparisons.