Fig. 3.
BMP-7 gene delivery stimulates dental implant osseointegration. (A) Histological staining overlaid with calcein bone fluorochrome to demarcate new and old bone from Ad/BMP-7-treated defect at 28 days at low power (1× magnification). (B) The defect border is clearly evident, and the new bone is bridging the defect and the implant surface (2× original magnification). (C) New bone-to-implant contact can be noted along the implant surface from the break-out box noted in (B). (D) Scanning electron microscopic image demonstrating intimate contact of new alveolar bone with the dental implant surface (1000× original magnification). Arrow points to the base of the osteotomy defects, while arrowheads point to the new bone-to-implant contact.