Skip to main content
. Author manuscript; available in PMC: 2009 Oct 24.
Published in final edited form as: Biochem Biophys Res Commun. 2008 Aug 14;375(3):341–345. doi: 10.1016/j.bbrc.2008.07.163

Figure 1.

Figure 1

Ribavirin impedes eIF4E mediated apoptotic rescue of serum-starved fibroblasts. (A) Chemical structures of m7-guanosine (m7G), ribavirin and tiazofurin. R represents the d-ribose sugar. (B) 1µM ribavirin, but not 1µM tiazofurin, inhibits eIF4E mediated rescue in murine fibroblasts as quantified by Annexin V – propidium iodide (PI) flow cytometry (bar color is as follows: blue – Annexin V−/PI−; yellow – Annexin V+/PI−; red – Annexin V+/PI+; black – Annexin V−/PI+; NC, normal controls; SS, serum starved; standard deviation is less than 9% for all measurements), and visualized by (C) TUNEL assays (blue – DAPI (viable), red – apoptotic; scale bar represents 100µm).

HHS Vulnerability Disclosure