TABLE 4.

RRs (95% CIs) from Cox proportional hazards models of a major CVD event (nonfatal MI, nonfatal stroke or CVD death) among men in the Physicians’ Health Study (1982–2005), according to change in BMI over prior 8 years, stratified by baseline age

	Age-adjusted	Multivariable*	Multivariable + BMI†
Change in BMI
< 60 years
<−0.5	1.18	1.15	1.18
(n=1,868)	(0.95–1.47)	(0.92–1.43)	(0.95–1.46)
−0.5 to <0.5	1.00 (ref)	1.00 (ref)	1.00 (ref)
(n=3,210)
0.5 to <2.0	1.06	1.05	0.94
(n=4,155)	(0.88–1.27)	(0.87–1.26)	(0.78–1.14)
≥2.0	1.55	1.51	0.97
(n=1,693)	(1.24–1.93)	(1.21–1.88)	(0.75–1.25)
≥60 years
<−0.5	1.33	1.30	1.33
(n=885)	(1.10–1.61)	(1.07–1.57)	(1.09–1.61)
−0.5 to <0.5	1.00 (ref)	1.00 (ref)	1.00 (ref)
(n=795)
0.5 to <2.0	0.94	0.91	0.88
(n=484)	(0.74–1.21)	(0.71–1.17)	(0.68–1.13)
≥2.0	1.12	1.09	0.93
(n=140)	(0.77–1.63)	(0.75–1.59)	(0.61–1.42)

BMI=body mass index

^*adjusted for age, level of physical activity, alcohol use, and history of past cigarette smoking

^†further adjusted for BMI (kg/m²) at 8 years

P, interaction=0.01