Sequence analysis of yeast SNARE proteins. (A)
Nearest-neighbor dendrogram of known and putative yeast SNARE
molecules. Common protein names or ORF numbers are indicated. The
dendrogram was generated with the PILEUP program of the GCG sequence
analysis package. (B) Multiple sequence alignment of S.
cerevisiae Vti1p (denoted S.c.Vti1p), and Vti1p-related
proteins from S. pombe (S.p.Vti1), human (hVti1-rp1 and
hVti1-rp2), and mouse (mVti1-rp1 and mVti1-rp2). Blackened boxes denote
identical residues, and gray shading denotes conserved residues.
Optimal alignment was produced with the PILEUP program. S.p.Vti1 is
encoded by cDNA clone D89116 and mVti1-rp1, mVti1-rp2, hVti1-rp1, and
hVti1-rp2 are encoded by EST AA056932, EST AA016379, EST AA105524, and
EST T70362, respectively. In some cases, primary sequence data were
obtained from the Washington University Genome Sequencing Center and
used to extend the EST sequences to encompass the complete ORFs.