Table 3. Odds ratios and p values for allelic and genotypic frequencies of rs1048661, rs3825942, and rs2165241 in comparison between cases (EX, EG, and EX+EG) and controls (CT, PG, NG, and PG+NG).
| Parameter |
EX |
EG |
EX+EG |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Versus CT | Versus PG | Versus NG | Versus PG+NG | Versus CT | Versus PG | Versus NG | Versus PG+NG | Versus CT | Versus PG | Versus NG | Versus PG+NG | |
|
rs1048661 | ||||||||||||
| Allele | ||||||||||||
| p value |
1.69x 10–23 |
3.23x 10–13 |
2.55x 10–16 |
4.08x 10–19 |
5.65x 10–33 |
1.92x 10–17 |
1.32x 10–21 |
4.71x 10–26 |
3.00x 10–45 |
2.61x 10–20 |
4.40x 10–26 |
1.18x 10–33 |
| OR |
19.71 |
16.67 |
18.39 |
17.64 |
28.23 |
23.88 |
26.35 |
25.27 |
23.97 |
20.27 |
22.37 |
21.45 |
| 95% CI |
8.90–43.67 |
6.91–40.22 |
7.84–43.14 |
7.80–39.88 |
12.83–62.14 |
9.96–57.27 |
11.31–61.41 |
11.25–56.76 |
13.40–42.87 |
10.14–40.56 |
11.60–43.16 |
11.67–39.43 |
| Genotype | ||||||||||||
| p value |
4.11x 10–25 |
1.16x 10–11 |
1.91x 10–17 |
2.31x 10–19 |
4.80x 10–32 |
2.12x 10–14 |
6.50x 10–21 |
3.42x 10–24 |
3.78x 10–43 |
1.04x 10–16 |
2.74x 10–25 |
3.57x 10–31 |
|
rs3825942 | ||||||||||||
| Allele | ||||||||||||
| p value |
1.77x 10–8 |
2.10x 10–33 |
2.10x 10–33 |
2.10x 10–33 |
2.42x 10–22 |
6.48x 10–8 |
4.72x 10–9 |
1.23x 10–10 |
3.98x 10–16 |
8.68x 10–10 |
1.47x 10–11 |
1.84x 10–14 |
| OR |
28.21 |
29.25 |
29.93 |
29.64 |
39.78 |
41.25 |
42.21 |
41.8 |
34 |
35.25 |
36.07 |
35.72 |
| 95% CI |
3.86–205.97 |
3.79–225.66 |
3.96–226.36 |
4.01–219.07 |
5.46–289–78 |
5.36–317.49 |
5.59–318.47 |
5.67–308.20 |
8.23–140.45 |
7.91–157.16 |
8.31–156.49 |
8.50–150.11 |
| Genotype | ||||||||||||
| p value |
2.10x 10–33 |
2.10x 10–33 |
2.10x 10–33 |
2.10x 10–33 |
3.53x 10–11 |
7.19x 10–8 |
2.88x 10–9 |
1.11x 10–10 |
6.37x 10–16 |
1.20x 10–9 |
1.00x 10–11 |
1.17x 10–14 |
|
rs2165241 | ||||||||||||
| Allele | ||||||||||||
| p value |
4.79x 10–5 |
0.3051 |
1.03x 10–33 |
1.20x 10–3 |
7.87x 10–7 |
0.1022 |
4.87x 10–6 |
8.28x 10–5 |
1.08x 10–9 |
0.0729 |
1.52x 10–7 |
3.02x 10–6 |
| OR |
16.59 |
4.56 |
18.87 |
12.39 |
23.4 |
6.43 |
26.61 |
17.47 |
20 |
5.49 |
22.74 |
14.93 |
| 95% CI |
2.25–122.20 |
0.47–44.63 |
2.45–145.49 |
1.63–94.08 |
3.18–171.92 |
0.66–62.81 |
3.46–204.70 |
2.31–132.36 |
4.78–83.62 |
0.90–33.46 |
5.11–101.30 |
3.42–65.14 |
| Genotype | ||||||||||||
| p value | 1.95x 10–4 | 0.3 | 1.59x 10–4 | 2.82x 10–3 | 5.14x 10–6 | 0.1004 | 7.16x 10–6 | 1.23x 10–4 | 1.07x 10–8 | 0.0715 | 2.79x 10–7 | 4.71x 10–6 |
OR, odds ratio; CI, confidence interval; NA, not applicable; EX, exfoliation syndrome; EG, exfoliation glaucoma; PG, primary open-angle glaucoma aged 70 years or older; NG, normal tension glaucoma aged 70 years or older; and CT, cataract aged 70 years or older. p values were obtained by Fisher's exact probability test.