1A: plasma testosterone concentrations, 1B: plasma free-testosterone concentrations, 1C: plasma androstenedione concentrations. IR: insulin resistant women, IS: insulin sensitive women: PCOS: polycystic ovary syndrome, Normal: normally ovulating women, PCOS-IR (n=11), PCOS-IS (n=12), Normal-IR (n=12), Normal-IS (n=8), disease: comparison between PCOS and normally ovulating women, IS: comparison between insulin sensitive and insulin resistant women, disease*IS: interaction between disease state (PCOS vs. Normal) and insulin sensitivity. The statistical significance was calculated by two-way ANOVA.