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. 2008 Nov 7;4(11):e1000246. doi: 10.1371/journal.pgen.1000246

Figure 2. Fine structure mapping of the huu locus.

Figure 2

(A) Physical map showing the location of the microsatellite markers used to map huu on CFA03. Microsatellite markers are listed below the line, and distances in Mb are shown above the line. (B) The haplotypes of recombinant (Rec) and non recombinant (Non Rec) backcross dogs are depicted with Dalmatian haplotypes in white and the Pointer haplotype in grey. A “V” indicates that the alleles were variable in Dalmatians. The first recombinant was not informative for MS173. The recombinants localized huu between MS8 and MS153. The maximum LOD score calculated for each microsatellite for all members of the family is shown at the bottom of the figure. The uric acid to creatinine ratio (UA/Cr), with the standard deviation in parenthesis, the number of dogs in each class (#), and the inferred huu genotype (G) are shown for dogs born since 2006 (28). The range of Uric acid/creatinine ratios for the low uric acid dogs is 0.23 to 0.47, and the range for high uric acid dogs is 1.2 to 4.0.