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. 2008 Oct 28;6(10):e254. doi: 10.1371/journal.pbio.0060254

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© 2008 Kappeler et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) bIGF1RKO^+/− adipocytes from inguinal AT were abnormally enlarged.

(B) Leptinemia was very high in bIGF1RKO^+/− mice, and strongly correlated with individual total AT size in all animals (R = 0.76, p < 0.0001, n = 82).

(C) Glucose tolerance was impaired in bIGF1RKO^+/− males and females.

(D) 30 min after intraperitoneal glucose injection (T30), the plasma insulin concentration was, as expected, significantly increased in mutants and controls. However, although bIGF1RKO^+/− females responded to elevated blood glucose with adequate hyperinsulinemia, bIGF1RKO^+/− males did not, suggesting a secretory defect.