Figure 2. RNA-Binding Proteins Bind mRNAs Encoding Functionally and Cytotopically Related Proteins.

(A) Enrichment of “cellular component” GO terms (rows) in target sets (1% FDR) of RBPs (columns). The significance of enrichment of the GO term is represented as a heat map (scale is to the left of the figure) in which the color intensity corresponds to the negative log₁₀ p-value, calculated using the hypergeometric density distribution function and corrected for multiple hypothesis testing using the Bonferroni method. Only a subset of significantly enriched GO terms are shown. RBPs whose targets are significantly enriched (p ≤ 0.01) for at least one “cellular component” or “biological process” GO term are shown.

(B) Same as in (A), except for “biological process” GO terms.