Figure 5. Wip1 inhibition enables senescence in cRb^−/−/Ras^V12 astrocytes.

a, All the experimental groups were treated with the Wip1 chemical inhibitors CCT007093 and Arsenic Trioxide (ATO). Levels of p-p38MAPK were assessed by Western blot analysis as a readout of Wip1 phosphatase activity inhibition. b, SA-β-galactosidase assays in all groups (without treatment, ATO treatment, CCT007093 treatment). The y-axis represents the percentage of-positive cells (mean and s.d.).