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. 2008 Oct 17;5(6):295–302. doi: 10.7150/ijms.5.295

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Effects of maternal cocaine administration on Bax and Bcl-2 protein expression in fetal rat brain. Cocaine was administered subcutaneously to the pregnant rats for 7 days as described in Methods. Immunoblot analysis of Bax and Bcl-2 proteins was performed in fetal rat brain. The top panel shows the representative immunoblots obtained for Bcl-2 and Bax at the expected size of 26 kDa and 21 kDa, respectively, and shows an increase in Bcl-2 and Bax in the brains treated with cocaine. The middle panel shows quantitative data obtained from five separate experiments. The bottom panel shows the Bax-to-Bcl-2 ratio in fetal rat brain. Data are expressed as % of control, and are means ± SEM. *P<0.05 vs. control.