Figure 4.

Albumin secretion by rat hepatocytes cocultivated with WT-CHO cells on substrates presenting increasing concentrations of recombinant T-cadherin protein. Function in cocultures containing T-cad+ CHO cells (no recombinant T-cadherin protein present on substrate) is shown for reference. Data represent cumulative albumin secretion for days 8–14 of coculture. Similar trends were seen for at least 2 wk in 2 independent biological repeat experiments. *P < 0.05, **P < 0.01, ***P < 0.001; 1-way ANOVA and Tukey’s post hoc test. Error bars = sem (n=3).