Table 3.

Familial TCCUT - Literature Summary of Multiple-Case Families

Article	Number Affected ^###	Relation to probands	Gender	Bladder TCC	Age at Onset	Other TCC	Age at Onset	Other CA	Age at Onset	Family History of CA^#	Smoke	Other Exposures^##
Burkland, 1966	2	Self	F	Y	70	Ureter	68			Sister-Colon
Burkland, 1966	2	Son	M	N		Ureter	53			Sister-Colon	Y
Fraumeni, 1967 Blattner, 1983^*	5	Self	M	Y	58			Lung (Large cell)	72	Mother-Colon, 78 Sibling (M)-Bladder, 64 (squamous cell) Brother-NOS, 70d Sister-NOS, 89	Y
		Sibling	M	Y	59			Lung (Oat cell)	77		Y
		Sibling	F	Y	70						Y
		Paternal Cousin	F	Y	66						Y
		Father	M	Y	54						Y
Benton, 1973	2	Self	M	Y	19							Furniture shop/Machinist
Benton, 1973	2	Father	M	Y	?							Welder
McCullough, 1975	6	Self	M	Y	36	Ureter	40			Paternal uncle-Melanoma, 63 Paternal cousin^-Ovary, Brain Paternal cousin^-Cervix Paternal cousin^-Leukemia Paternal cousin^*-Breast	Y
		Sibling	M	Y	35	Ureter/Renal pelvis	47	Basal Cell	?		Y	Printer
		Father	M	Y	44			Gastric (adenocarcinoma)	63		Y	Painter early 20’s
		Paternal uncle^**	M	Y	65			Lung metastases, primary unknown	81		N	Mechanic
		Paternal Cousin^**	F	Y	48			Cervix	38		N	Lived on farm
		Paternal uncle^***	M	Y	60			Prostate	60		Y	Farmer
Leklem, 1976	2	Self	F	Y	65					Mother-Breast	Y	Art teacher
Leklem, 1976	2	Brother	M	Y	51					Mother-Breast	Y	Engineer diesel train/Petroleum plant operator
Sharma, 1976	2	Self	M	Y	83						Y
	2	Son	M	Y	58
	2	Self	M	Y	53
	2	Sibling	M	N		Renal pelvis	56
Purtilo, 1979	2	Self	M	Y	62						Y	Textile dye
	2	Sibling	M	Y	55						Y	Machinist
	2	Self	M	Y	59					Brother-Colon, 62 Sister-Breast, 58	Y	Rubber/textile dye
	2	Sibling	M	Y	56					Brother-Colon, 62 Sister-Breast, 58	Y	Leather
	2	Self	M	Y	91			Prostate	89		N
	2	Sibling	F	Y	89						N
	2	Self	M	Y	39			Renal Cell	57		Y	Machinist
	2	Sibling	M	Y	52
	3	Self	M	Y	33						Y	Bricklayer
		Daughter	F	Y	19						N	Tool and dye
		Sibling	M	Y	28						Y	Bricklayer
	2	Self	M	Y	73					Daughter-Liver, 54	Y	Electrician
	2	Son	M	Y	62					Daughter-Liver, 54	Y	Electrician
Lynch, 1979	3	Self	M	Y	52					Daughter-Neuroblastoma, 4 wks Paternal GM, GGM-Breast Paternal uncle-NOS	N	Organic chemist
		Father	M	Y	68						Y	Radiologist
		Paternal Uncle	M	N		Renal pelvis	62				Y
	3	Self	M	Y	50			Basal Cell	50	Father-Colon, 73	Y	Wiring for railroad
		Sibling	M	Y	24	Renal pelvis	48				Y
		Sibling	M	Y	49						Y
Mahboubi, 1981	3	Self	F	Y	66	Ureter	66			Mother, MGM, MGGM, M aunt- Skin, Bone, Leukemia	N
		Sibling	M	Y	64						Y	Farmer
		Son	M	Y	50						Y	Pilot/Construction/Farmer
Marchetto, 1983	3	Self	F	N		Ureter	48	Endometrial carcinoma	50	Maternal aunt-Breast, 65 Maternal uncle-Liver, 67 Maternal uncle-Lung, 73 Maternal uncle-Gastric Maternal GF-Brain, 42	N
		Mother	F	Y	60	Lower Ureter	57	Renal cell	57		Y	Shoemaker
		Maternal Cousin	F	Y	69	Lower Ureter	69	Endometrial carcinoma	68		N	Leather industry
Orphali, 1986	3	Self	M	N		Renal pelvis	64			Sister-Cervix Father – Lymphosarcoma 4 Paternal uncles-NOS MGF, M aunt, M uncle - NOS	N
		Sibling	M	N		Renal pelvis	55				Y
		Sibling	F	N		Upper Ureter	60				Y
Eglisson, 1993	3	Self	F	Y	76					Daughter-Renal Cell, 67; Breast, 67;Colon, 72 Paternal 2^nd cousins-Skin, 72; Kidney, 58;Breast, 54;Colon, 54 Paternal 3^rd cousin-Leukemia, 9	N	Farm
		Son	M	Y	81	Renal pelvis	78				Y	Farm
		Daughter	F	N		Renal pelvis, Ureter	70	Thyroid (Papillary)	73		N	Farm
Kenet, 1995	2	Self	F	Y	14			Acute lymphocytic leukemia	8.5		N	Treated with Cyclophosphamide
Kenet, 1995	2	Grandfather	M	Y	?
Schoenberg, 1996	2	Self	M	Y	29	Renal pelvis	29			Brother-Melanoma, 27 Father-Prostate, 68 MGF-Lung		Multiple SAB t(5;20)(p15;q11)
Schoenberg, 1996	2	Mother	F	Y	65					Brother-Melanoma, 27 Father-Prostate, 68 MGF-Lung		Multiple SAB
Aben, 2001 Kiemeney, 2006	2	Self	F	^****	42
	2	Mother	F	^****	42
	2	Self	F	^****	54
	2	Mother	F	^****	74
	3	Self	M	^****	73					Father-Stomach Mother-?Bone Sibling-’Neck’,61;Colon, 60
		Sibling	M	^****	65
		Sibling	M	^****	55
	3	Self	F	^****	43			Endometrial	?	Mother-?Vulvar Siblings-Colon, 34;Ovary, 41; Stomach, 38 Father - Colon; Stomach, 34
		Sibling	M	^****	43
		Maternal Grandfather	M	^****	36
	3	Self	M	^****	54
		Mother	F	^****	46
		Sibling	F	^****	53
	3	Self	M	^****	?	ureter	38
		Father	M	^****	67
		Paternal Grandfather	M	^****	60
	3	Self	M	^****	66			Lung	54	Sibling-Esophagus, 72 Sibling-Lung
		Sibling	M	^****	60
		Father	M	^****	82			Colon	52
	3	Self	M	^****	72					Father-Liver, 43 Sibling-Breast, 62 Sibling-Stomach, 53 Paternal Sibling-Stomach, 72
		Sibling	M	^****	65			Prostate	?
		Paternal Uncle	M	^****	58
	3	Self	F	^****	53					Sibling-Lung, 49 Sibling-Prostate, 57
		Sibling	M	^****	61
		Sibling	M	^****	?
	2	Self	F	^****	70
	2	Sibling	M	^****	58
	3	Self	M	^****	40					Paternal Sibling-Breast
		Father	M	^****	70
		Paternal Grandmother	F	^****	92

Relationships cited are with reference to the proband.

^##

Shaded occupations have been suggested as potential contributors to TCCUT.

^###

Shaded families present features suggestive of HNPCC.

Also contains previously unpublished data, See Figure 1 for updated pedigree

^**

Nuclear family

^***

Nuclear family

^****

Site not specified

NOS = Not otherwise specified

? = not reported

SAB = spontaneous abortion

Blank spaces indicate that data was not reported