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(A) Total and (B) inhibitory anti-rFVIII antibody titers in hemophilic mice following administration of rFVIII in the absence or presence of liposomes of DMPC/BPS (70/30) of varying sizes at the end of 6 weeks. Treatment was administered via s.c. route. Each point represents values from individual animals and the horizontal bar depicts the mean titer. Blood samples were obtained 2 weeks after the fourth injection.
