Table 1.

Mean Anti-rFVIII Total Titers After the End of 6 Weeks Following Immunization of Hemophilic Mice with rFVIII in the Absence and Presence of Liposomes of Varying Size and Composition

Liposome Size (nm) and Composition	Total Antibody Titers (±SEM)	Reduction in Total Titers (Relative to Control) (%)
Control (free rFVIII)	13167±2042 (n=12)	—
80 nm DMPC/BPS (70:30)	7057±807* (n=15)	∼46
200 nm DMPC/BPS (70:30)	5700±1255* (n=15)	∼57
400 nm DMPC/BPS (70:30)	4030±496* (n=12)	∼69
80 nm DMPC	9681±2586 (n=12)	∼26
200 nm DMPC	6075±1114* (n=15)	∼54
400 nm DMPC	6403±1730* (n=12)	∼51

^*p<0.05, statistical analysis was carried out as described under Materials and Methods Section.